Pure Appl. Chem., 2008, Vol. 80, No. 4, pp. 763-776
http://dx.doi.org/10.1351/pac200880040763
Synthesis of optically active heterocyclic compounds using Pd-catalyzed asymmetric reactions as a key step
Abstract:
Highly enantioselective Pd(II)-catalyzed Michael addition, Mannich-type reaction, aldol reaction, fluorination, conjugate addition of amine, and conjugate reduction have been developed. Asymmetric synthesis of biologically interesting heterocyclic compounds, calycotomine, BMS-204352, torcetrapib, and warfarin, was achieved by using these Pd-catalyzed asymmetric reactions as a key step.