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Pure Appl. Chem., 2008, Vol. 80, No. 4, pp. 707-715

General and practical synthesis of benzothiazoles

Toshiaki Mase and Takahiro Itoh

Process Research, Preclinical Development, Banyu Pharmaceutical Co., Ltd. Okubo 3, Tsukuba, Ibaraki 300-2611, Japan

Abstract: The carbon-sulfur bond formation of aryl bromides and triflates catalyzed by a new catalyst system, Pd2(dba)3/xantphos, has been demonstrated. Based on this finding, a novel and practical synthesis of benzothiazoles has been developed. This new methodology allows for the assembly of a wide range of benzothiazoles.