Pure Appl. Chem., 2008, Vol. 80, No. 4, pp. 707-715
http://dx.doi.org/10.1351/pac200880040707
General and practical synthesis of benzothiazoles
Abstract:
The carbon-sulfur bond formation of aryl bromides and triflates catalyzed by a new catalyst system, Pd2(dba)3/xantphos, has been demonstrated. Based on this finding, a novel and practical synthesis of benzothiazoles has been developed. This new methodology allows for the assembly of a wide range of benzothiazoles.
Keywords
aryl bromides; aryl triflates; benzothiazole; palladium-catalyzed coupling; thiol surrogates; xantphos.