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Pure Appl. Chem., 2007, Vol. 79, No. 9, pp. 1531-1540

Self-supported chiral catalysts for heterogeneous enantioselective reactions

Kuiling Ding, Zheng Wang and Lei Shi

State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, China

Abstract: The development of a new strategy to immobilize the homogeneous chiral catalysts for enantioselective reactions is highly desirable in order to overcome some drawbacks of conventional approaches. In this lecture, a conceptually new strategy for heterogenization of homogeneous chiral catalysts (i.e., "self-supporting" approach) is presented. The concept focuses on the use of homochiral metal-organic coordination polymers generated by self-assembly of chiral multitopic ligands with metal ions as the heterogeneous catalysts, and thus obviating the need of any exogenous support. The application of this "self-supporting" strategy has been exemplified in heterogeneous catalysis of asymmetric carbonyl-ene, sulfoxidation, and epoxidation, as well as asymmetric hydrogenation reactions.