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Pure Appl. Chem., 2007, Vol. 79, No. 4, pp. 753-761

From natural products to biological tools

Peter Wipf, Thomas H. Graham and Jingbo Xiao

Department of Chemistry and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA

Abstract: The development of a total synthetic approach for the antimitotic disorazole C1 and the design of a peptide isostere linked to the reactive oxygen scavenger 2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPO) demonstrate established as well as novel strategies for mining the therapeutic potential of natural products.