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Pure Appl. Chem., 2007, Vol. 79, No. 4, pp. 615-626

http://dx.doi.org/10.1351/pac200779040615

Structural development studies of nuclear receptor ligands

Shinnosuke Hosoda and Yuichi Hashimoto

Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan

Abstract: Studies in our laboratory are focused on structural development studies of biological response modifiers (BRMs), including nuclear receptor (NR) ligands, which act directly on cells at the gene expression level, and thalidomide (and related molecules), which modulates a variety of physiological processes. Our studies on the molecular design of ligands for retinoic acid receptor (RAR), androgen receptor (AR), vitamin D receptor (VDR), farnesoid X receptor (FXR), and peroxisome proliferator-activated receptor (PPAR) are reviewed.