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Pure Appl. Chem., 2007, Vol. 79, No. 4, pp. 603-614

http://dx.doi.org/10.1351/pac200779040603

Discovery of micafungin (FK463): A novel antifungal drug derived from a natural product lead

Akihiko Fujie

Fermentation Research Laboratories, Astellas Pharma Inc., 5-2-6 Tokodai, Tsukuba, Ibaraki 300-2698, Japan

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  • Bauer Armin, Brönstrup Mark: Industrial natural product chemistry for drug discovery and development. Nat. Prod. Rep. 2014, 31, 35. <http://dx.doi.org/10.1039/c3np70058e>
  • Emri Tamás, Majoros László, Tóth Viktória, Pócsi István: Echinocandins: production and applications. Appl Microbiol Biotechnol 2013, 97, 3267. <http://dx.doi.org/10.1007/s00253-013-4761-9>
  • Yamada Masato, Yawata Kazunobu, Orino Yohsuke, Ueda Satoshi, Isogai Yasuhiro, Taguchi Goro, Shimosaka Makoto, Hashimoto Seiji: Agrobacterium tumefaciens-mediated transformation of antifungal lipopeptide producing fungus Coleophoma empetri F-11899. Curr Genet 2009, 55, 623. <http://dx.doi.org/10.1007/s00294-009-0275-5>
  • Hashimoto Seiji: Micafungin: a sulfated echinocandin. J Antibiot 2009, 62, 27. <http://dx.doi.org/10.1038/ja.2008.3>