Pure Appl. Chem., 2007, Vol. 79, No. 2, pp. 281-291
http://dx.doi.org/10.1351/pac200779020281
Biomimetic synthesis via polyepoxide cyclizations
Abstract:
The biomimetic synthesis of trans,syn,trans-fused polycyclic ether natural products involving a cascade of stereospecific and regioselective oxacyclizations of polyepoxide substrates is described as applied to the synthesis of polyoxepane and polypyran structures. In addition, an extension of biomimetic polyene cyclizations to terpenoid natural products is outlined.
Keywords
biomimetic synthesis; polycyclic ethers; polycyclic terpenes; polyepoxides; tandem cyclizations.