Pure Appl. Chem., 2006, Vol. 78, No. 2, pp. 231-239
http://dx.doi.org/10.1351/pac200678020231
Palladium-mediated cascade or multicomponent reactions: A new route to carbo- and heterocyclic compounds
Abstract:
In recent years, new processes based on transition-metal-mediated intramolecular addition reaction of heteronucleophiles and stabilized carbon nucleophiles to unactivated alkenes and alkynes have been developed in our laboratory. In this article, we summarize a number of recent synthetic applications of these new processes. Emphasis is placed on the development of multicomponent reactions based on a Pd-mediated intramolecular cyclization coupled with a carbon-carbon bond-forming reaction. Applications of this methodology to the synthesis of natural lignans are also reported.