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Pure Appl. Chem., 2006, Vol. 78, No. 12, pp. 2297-2304

Oxidative damage to DNA: Inhibition of guanine damage

Sriram Kanvah and Gary B. Schuster

School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332, USA

Abstract: One-electron oxidation of DNA results in chemical damage to nucleobases, particularly guanine in multiple G sequences. Oxidation may be triggered by numerous events, including photosensitization. We describe studies of photoinduced oxidations of DNA triggered by irradiation of covalently linked anthraquinone derivatives under various conditions that affect the global structure of the DNA. These structural changes have subtle effects on the result of the one-electron oxidation.