Pure Appl. Chem., 2006, Vol. 78, No. 12, pp. 2297-2304
http://dx.doi.org/10.1351/pac200678122297
Oxidative damage to DNA: Inhibition of guanine damage
Abstract:
One-electron oxidation of DNA results in chemical damage to nucleobases, particularly guanine in multiple G sequences. Oxidation may be triggered by numerous events, including photosensitization. We describe studies of photoinduced oxidations of DNA triggered by irradiation of covalently linked anthraquinone derivatives under various conditions that affect the global structure of the DNA. These structural changes have subtle effects on the result of the one-electron oxidation.
Keywords
damage repair; DNA; guanine damage; molecular wire; nanoelectronics; oxidative damage.