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Pure Appl. Chem., 2006, Vol. 78, No. 10, pp. 1857-1866

Synthesis of fine chemicals by the conjugate addition of nitroalkanes to electrophilic alkenes

R. Ballini, L. Barboni, G. Bosica, D. Fiorini and A. Palmieri

Dipartimento di Scienze Chimiche dell'Università di Camerino, Via S. Agostino 1, 62032 Camerino, Italy

Abstract: Several aliphatic nitro compounds have been employed as stabilized carbanions in the conjugate addition to a variety of electron-poor alkenes (Michael reaction). Depending on the nature of the alkene, new carbon-carbon single or double bonds can be generated. However, all the Michael adducts can be efficiently utilized as key building blocks for the synthesis of a huge array of fine chemicals, including homo- and heterocyclic structures.