Critical evaluation of stability constants of metal complexes of complexones for biomedical and environmental applications* (IUPAC Technical Report)

Anderegg, Giorgio; Arnaud-Neu, Francoise; Delgado, Rita; Felcman, Judith; Popov, Konstantin

doi:10.1351/pac200577081445

Pure Appl. Chem., 2005, Vol. 77, No. 8, pp. 1445-1495

http://dx.doi.org/10.1351/pac200577081445

ANALYTICAL CHEMISTRY DIVISION

Critical evaluation of stability constants of metal complexes of complexones for biomedical and environmental applications* (IUPAC Technical Report)

Giorgio Anderegg¹, Francoise Arnaud-Neu², Rita Delgado³, Judith Felcman⁴ and Konstantin Popov⁵*

¹ Laboratory of Inorganic Chemistry, Swiss Federal Institute of Technology, ETH, Wolfgang Pauli Strasse 10, CH 8093 Zürich, Switzerland
² Laboratoire de Chimie-Physique, UMR 7512 (CNRS‑ULP), ECPM, 25, rue Becquerel, 67087 Strasbourg Cédex 02, France
³ Instituto de Tecnologia Química e Biológica (ITQB), Apartado 127, 2781-901 Oeiras, Portugal and Instituto Superior Técnico, Av. Rovisco Pais, 1049-001 Lisboa, Portugal
⁴ Pontificia Universidade Católica do Rio de Janeiro, Rua Marques de São Vicente 225-Gávea, 22453-900 Rio de Janeiro-RJ, Brazil
⁵ Institute of Reagents and High Purity Substances (IREA), Bogorodsky val-3, 107258, Moscow, Russia and Moscow State University of Food Production, Volokolamskoye Sh. 11, 125080 Moscow, Russia

Abstract: Available experimental data on stability constants of proton (hydron) and metal complexes for seven complexones of particular biomedical and environmental interest: iminodiacetic acid [2,2'-azanediyldiacetic acid, IDA], (methylimino)diacetic acid [2,2'-(methylazanediyl)diacetic acid, MIDA]; 2,2',2'',2'''-{[(carboxymethyl)azanediyl]bis[(ethane-1,2-diyl)nitrilo]}tetraacetic acid (DTPA), 3,6,9,12-tetrakis(carboxymethyl)-3,6,9,12-tetraazatetradecanedioic acid (TTHA); 2,2',2''-(1,4,7-triazonane-1,4,7-triyl)triacetic acid (NOTA); 2,2',2'',2'''-(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl)tetraacetic acid (DOTA); 2,2',2'',2'''-(1,4,8,11-tetraazacyclotetradecane-1,4,8,11-tetrayl)tetraacetic acid (TETA), published in 1945-2000, have been critically evaluated. Some typical errors in stability constant measurements for particular complexones are summarized. Higher quality data are selected and presented as “Recommended” or “Provisional”.