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Pure Appl. Chem., 2005, Vol. 77, No. 7, pp. 1251-1257

Combinatorial approach to the discovery of chiral catalysts for asymmetric reactions

Kuiling Ding

State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, China

Abstract: The powerfulness of a combinatorial approach in the discovery of novel chiral catalyst systems, particularly for the development of highly efficient, enantioselective, and practical catalysts for asymmetric reactions, was demonstrated by screening modular chiral catalyst libraries created by the strategy of two-component ligand modification of metal ions on the basis of molecular recognition and assembly.