Pure Appl. Chem., 2005, Vol. 77, No. 7, pp. 1235-1241
http://dx.doi.org/10.1351/pac200577071235
Diastereoselective alkylation of cyclo-β-dipeptides en route to enantiopure β-amino acids
Abstract:
The cyclization of various β-amino acids with PhP(O)Cl2 affords cyclo-β-dipeptides, whose boat conformation is probably responsible for the high diastereoselectivity observed in the alkylation reactions of their lithium enolate derivatives.
Keywords
diastereoselective reactions; enantioselective; pyrimidinones; β-amino acids; β-peptides.