Pure Appl. Chem., 2005, Vol. 77, No. 7, pp. 1207-1212
http://dx.doi.org/10.1351/pac200577071207
Ring-closing metathesis: A facile construct for alkaloid synthesis
Abstract:
Ring-closing metathesis has been found to be a highly effective reaction for the synthesis of functionalized, bridged nitrogen heterocycles. The utility of the process has been established in several case studies, including a facile synthesis of the tropane ring system and efficient, enantioselective syntheses of the natural products (–)-peduncularine and (+)‑anatoxin-a.
Keywords
alkaloids; enantioselective; heterocycles; ring-closing metathesis; stereoselective.