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Pure Appl. Chem., 2005, Vol. 77, No. 7, pp. 1115-1130

http://dx.doi.org/10.1351/pac200577071115

Development of methods suitable for natural product synthesis: The azadirachtin story

Steven V. Ley

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK

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  • Łozowicka B., Kaczyński P., Magdziarz T., Dubis A.T.: Synthesis, antifeedant activity against Coleoptera and 3D QSAR study of alpha-asarone derivatives. SAR and QSAR in Environmental Research 2014, 25, 173. <http://dx.doi.org/10.1080/1062936X.2013.875061>
  • Łozowicka Bożena, Kaczyński Piotr: Synthesis and antifeedant activity of novel alpha-asarone derivatives against stored-product pests. Pest. Manag. Sci 2013, 69, 964. <http://dx.doi.org/10.1002/ps.3461>
  • Heasley Brian: Synthesis of Limonoid Natural Products. Eur J Org Chem 2011, 2011, 19. <http://dx.doi.org/10.1002/ejoc.201001218>
  • Tan Qin-Gang, Luo Xiao-Dong: Meliaceous Limonoids: Chemistry and Biological Activities. Chemistry Review 2011, 111, 7437. <http://dx.doi.org/10.1021/cr9004023>
  • Dayoub Wissam, Doutheau Alain: (E) Enol ethers from the stereoselective reduction of α-alkoxy-β-ketophosphonates and Wittig type reaction. Sci China Chem 2010, 53, 1937. <http://dx.doi.org/10.1007/s11426-010-4057-1>
  • Boyer Alistair, Veitch Gemma E., Beckmann Edith, Ley Steven V.: Second-Generation Synthesis of Azadirachtin: A Concise Preparation of the Propargylic Mesylate Fragment. Angew Chem 2009, 121, 1343. <http://dx.doi.org/10.1002/ange.200805395>
  • Boyer Alistair, Veitch Gemma E., Beckmann Edith, Ley Steven V.: Second-Generation Synthesis of Azadirachtin: A Concise Preparation of the Propargylic Mesylate Fragment. Angew Chem Int Ed 2009, 48, 1317. <http://dx.doi.org/10.1002/anie.200805395>
  • Duchowicz Pablo R., Goodarzi Mohammad, Ocsachoque Marco A., Romanelli Gustavo P., Ortiz Erlinda del V., Autino Juan. C., Bennardi Daniel O., Ruiz Diego M., Castro Eduardo A.: QSAR analysis on Spodoptera litura antifeedant activities for flavone derivatives. Sei Total Environ 2009, 408, 277. <http://dx.doi.org/10.1016/j.scitotenv.2009.09.041>
  • Veitch Gemma E., Boyer Alistair, Ley Steven V.: Die Azadirachtin-Story. Angew Chem 2008, 120, 9542. <http://dx.doi.org/10.1002/ange.200802675>
  • Veitch Gemma E., Boyer Alistair, Ley Steven V.: The Azadirachtin Story. Angew Chem Int Ed 2008, 47, 9402. <http://dx.doi.org/10.1002/anie.200802675>
  • Ley Steven V., Abad-Somovilla Antonio, Anderson James C., Ayats Carles, Bänteli Rolf, Beckmann Edith, Boyer Alistair, Brasca Maria G., Brice Abigail, Broughton Howard B.: The Synthesis of Azadirachtin: A Potent Insect Antifeedant. Chem Eur J 2008, 14, 10683. <http://dx.doi.org/10.1002/chem.200801103>
  • Ionkin Alex S., Marshall William J., Fish Brian M., Schiffhauer Matthew F., McEwen Charles N.: A stable enol in small ring systems: clear differentiation between penta- and tri-valency of phosphorus atoms. Chem Commun 2008, 5432. <http://dx.doi.org/10.1039/b809877h>
  • Watanabe Hidenori, Mori Naoki, Itoh Daisuke, Kitahara Takeshi, Mori Kenji: Synthetic Study Towards Azadirachtin: An Efficient and Stereoselective Construction of the AB Rings with Full Functionality. Angew Chem 2007, 119, 1534. <http://dx.doi.org/10.1002/ange.200604097>
  • Veitch Gemma E., Beckmann Edith, Burke Brenda J., Boyer Alistair, Maslen Sarah L., Ley Steven V.: Synthesis of Azadirachtin: A Long but Successful Journey. Angew Chem 2007, 119, 7773. <http://dx.doi.org/10.1002/ange.200703027>
  • Watanabe Hidenori, Mori Naoki, Itoh Daisuke, Kitahara Takeshi, Mori Kenji: Synthetic Study Towards Azadirachtin: An Efficient and Stereoselective Construction of the AB Rings with Full Functionality. Angew Chem Int Ed 2007, 46, 1512. <http://dx.doi.org/10.1002/anie.200604097>
  • Veitch Gemma E., Beckmann Edith, Burke Brenda J., Boyer Alistair, Maslen Sarah L., Ley Steven V.: Synthesis of Azadirachtin: A Long but Successful Journey. Angew Chem Int Ed 2007, 46, 7629. <http://dx.doi.org/10.1002/anie.200703027>
  • Ley Steven V.: Development of Methods Suitable for Natural Product Synthesis: The Azadirachtin Story. ChemInform 2005, 36. <http://dx.doi.org/10.1002/chin.200550267>