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Pure Appl. Chem., 2005, Vol. 77, No. 12, pp. 2121-2132

New chiral phosphorus ligands with spirobiindane backbone for asymmetric hydrogenations

Jian-Hua Xie, Shou-Fei Zhu, Yu Fu, Ai-Guo Hu and Qi-Lin Zhou

State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China

Abstract: Chiral spiro phosphorus ligands including monophosphoramidites and diphosphines, which contained 1,1'-spirobiindane as a backbone, were designed and synthesized. These spiro ligands were proven to be highly efficient for rhodium- and ruthenium-catalyzed asymmetric hydrogenations of prochiral olefins and ketones with excellent enantioselectivities.