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Pure Appl. Chem., 2005, Vol. 77, No. 11, pp. 1957-1964

http://dx.doi.org/10.1351/pac200577111957

Economic drug discovery and rational medicinal chemistry for tropical diseases

Kelly Chibale

Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa

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  • Wang Ning, Wicht Kathryn J., Imai Kento, Wang Ming-qi, Anh Ngoc Tran, Kiguchi Ryo, Kaiser Marcel, Egan Timothy J., Inokuchi Tsutomu: Synthesis, β-haematin inhibition, and in vitro antimalarial testing of isocryptolepine analogues: SAR study of indolo[3,2-c]quinolines with various substituents at C2, C6, and N11. Bioorganic & Medicinal Chemistry 2014. <http://dx.doi.org/10.1016/j.bmc.2014.03.030>
  • Kobo Patricia I., Ayo Joseph O., Aluwong Tagang, Zezi Abdulkadir U., Maikai Victor, Ambali Suleiman F.: Flavonoid mixture ameliorates increase in erythrocyte osmotic fragility and malondialdehyde concentration induced by Trypanosoma brucei brucei-infection in Wistar rats. Research in Veterinary Science 2014, 96, 139. <http://dx.doi.org/10.1016/j.rvsc.2013.10.005>
  • Pakravan Parvaneh, Kashanian Soheila, Khodaei Mohammad M., Harding Frances J.: Biochemical and pharmacological characterization of isatin and its derivatives: from structure to activity. Pharmacological Reports 2013, 65, 313. <http://dx.doi.org/10.1016/S1734-1140(13)71007-7>
  • Pervez Humayun, Manzoor Nazia, Yaqub Muhammad, Khan Khalid Mohammed: 5-Nitroisatin-derived thiosemicarbazones: potential antileishmanial agents. Journal of Enzyme Inhibition and Medicinal Chemistry 2013, 1. <http://dx.doi.org/10.3109/14756366.2013.836641>
  • Xu Zhigang, Ayaz Muhammad, Cappelli Alexandra A., Hulme Christopher: General One-pot, Two-Step Protocol Accessing a Range of Novel Polycyclic Heterocycles with High Skeletal Diversity. ACS Comb. Sci. 2012, 14, 460. <http://dx.doi.org/10.1021/co300046r>
  • Defaux Julien, Sala Marta, Formosa Xavier, Galdeano Carles, Taylor Martin C., Alobaid Waleed A.A., Kelly John M., Wright Colin W., Camps Pelayo, Muñoz-Torrero Diego: Huprines as a new family of dual acting trypanocidal–antiplasmodial agents. biorg med chem 2011, 19, 1702. <http://dx.doi.org/10.1016/j.bmc.2011.01.028>
  • Hulme Christopher, Dietrich Justin: Emerging molecular diversity from the intra-molecular Ugi reaction: iterative efficiency in medicinal chemistry. Mol Divers 2009, 13, 195. <http://dx.doi.org/10.1007/s11030-009-9111-6>
  • Rajur Raj (S. B.), Rao Venugopal N., Kim Hwa-Ok, Nagafuji Pamela, Hearult Xavier, Williams John D., Peet Norton P.: Efficient Synthesis of 7-Amino-3-hydroxyindan-1-one. Synth Comm 2009, 39, 626. <http://dx.doi.org/10.1080/00397910802419680>
  • Mahajan Aman, Yeh Susan, Nell Margo, van Rensburg Constance E.J., Chibale Kelly: Synthesis of new 7-chloroquinolinyl thioureas and their biological investigation as potential antimalarial and anticancer agents. Bioorganic & Medicinal Chemistry Letters 2007, 17, 5683. <http://dx.doi.org/10.1016/j.bmcl.2007.07.049>