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Pure Appl. Chem., 2005, Vol. 77, No. 1, pp. 91-101

Biopolyphenolics as antioxidants: Studies under an Indo-Italian CSIR-CNR project

Mario C. Foti1, Sunil K. Sharma2, Gaurav Shakya2, Ashok K. Prasad2, Giovanni Nicolosi1, Paolo Bovicelli3, Balaram Ghosh4, Hanumantharao G. Raj5, Ramesh C. Rastogi2 and Virinder S. Parmar2

1 Istituto di Chimica Biomolecolare del CNR, Sezione di Catania, Via del Santuario 110, 95028 Valverde (CT), Italy
2 Bioorganic Laboratory, Department of Chemistry, University of Delhi, Delhi 110 007, India
3 Istituto di Chimica Biomolecolare, CNR, Sezione di Roma, University of La Sapienza, I-00185, Roma, Italy
4 Molecular Immunology and Immunogenetics Laboratory, Institute of Genomics and Integrative Biology, Mall Road, Delhi 110 007, India
5 Department of Biochemistry, V. P. Chest Institute, University of Delhi, Delhi 110 007, India

Abstract: A wide variety of polyphenolic compounds (i.e., 4-methylcoumarins, xanthones, pyrazoles, and pyrazolylacrylonitriles) have been examined for their antioxidant effect on NADPH-catalyzed liver-microsomal lipid peroxidation with a view to establishing their structure–activity relationship. Dihydroxy-/diacetoxy-4-methylcoumarin derivatives have been shown to be radical scavengers. The effect of nine different xanthones has been examined on the modulation of cytokine-induced expression of intercellular adhesion molecule-1 (ICAM-1) in human endothelial cells. 1,4-Dihydroxyxanthone showed enhanced antioxidant activity as well as ICAM-1 inhibitory activity.