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Pure Appl. Chem., 2004, Vol. 76, No. 2, pp. 365-374

Synthesis of texaphyrin conjugates

D. J. Magda, Z. Wang, Nikolay Gerasimchuk, W.-H. Wei, P. Anzenbacher, Jr. and J. L. Sessler

Pharmacyclics Incorporated, 995 East Arques Avenue, Sunnyvale, CA 94085-4593 USA; Department of Chemistry & Biochemistry, 1 University Station A5300, The University of Texas at Austin, Austin, TX 78712-0165, USA

Abstract: This paper summarizes recent synthetic efforts devoted to the generation of new, second-generation texaphyrin-type drugs, specifically species that involve known or potential anticancer agents covalently attached to a tumor-localizing texaphyrin core. Particular emphasis will be placed on the strategies needed to prepare such systems, as well as on the choice of active group being subject to attachment.