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Pure Appl. Chem., 2003, Vol. 75, No. 2-3, pp. 375-388

Mevalonate-independent methylerythritol phosphate pathway for isoprenoid biosynthesis. Elucidation and distribution

M. Rohmer

Université Louis Pasteur/CNRS/Institut Universitaire de France, Institut Le Bel, 4 rue Blaise Pascal, 67070 Strasbourg Cedex, France

Abstract: A long-overlooked metabolic pathway for isoprenoid biosynthesis, the mevalonate-independent methylerythritol phosphate (MEP) pathway, is present in many bacteria and in the chloroplasts of all phototrophic organisms. It represents an alternative to the well known mevalonate pathway, which is present in animals, fungi, plant cytoplasm, archaebacteria, and some eubacteria. This contribution summarizes key steps of its elucidation and the state-of-the-art knowledge of this biosynthetic pathway, which represents a novel target for antibacterial and antiparasitic drugs.