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Pure Appl. Chem., 2003, Vol. 75, No. 2-3, pp. 179-186

Synthesis of carbohydrate-based antibiotics

C.-H. Wong, M. C. Bryan, P. T. Nyffeler, H. Liu and Eli Chapman

Department of Chemistry, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 9203, USA

Abstract: Tackling the problem of carbohydrate recognition is a subject of current interest. Our strategies in this regard include development of new methods for the synthesis of saccharides and sugar arrays for screening, design of d-peptides to target bacterial cell-surface sugars, preparation of mechanism-based inhibitors of the enzymes involved in the biosynthesis of saccharides and the synthesis of aminoglycoside mimetics to target RNA.