Pure and Applied Chemistry

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• Vranova Valerie, Lojkova Lea, Rejsek Klement, Formanek Pavel: Significance of the Natural Occurrence of L- Versus D-Pipecolic Acid: A Review. Chirality 2013, 25, 823. <http://dx.doi.org/10.1002/chir.22237>
• Yang Xiudong, Dong Changming, Chen Jian, Liu Qi, Han Bin, Zhang Quan, Chen Yue: Design, synthesis, and biological activities of triazole tubulysin V analogue. Tetrahedron Letters 2013, 54, 2986. <http://dx.doi.org/10.1016/j.tetlet.2013.03.127>
• Burkhart Jens L., Kazmaier Uli: A straightforward click-approach towards pretubulysin-analogues. RSC Adv 2012, 2, 3785. <http://dx.doi.org/10.1039/c2ra20191g>
• Floyd William C., Datta Gopal K., Imamura Shinichi, Kieler-Ferguson Heidi M., Jerger Katherine, Patterson Andrew W., Fox Megan E., Szoka Francis C., Fréchet Jean M. J., Ellman Jonathan A.: Chemotherapeutic Evaluation of a Synthetic Tubulysin Analogue-Dendrimer Conjugate in C26 Tumor Bearing Mice. ChemMedChem 2011, 6, 49. <http://dx.doi.org/10.1002/cmdc.201000377>
• Burkhart Jens L., Müller Rolf, Kazmaier Uli: Syntheses and Evaluation of Simplified Pretubulysin Analogues. Eur J Org Chem 2011, 2011, 3050. <http://dx.doi.org/10.1002/ejoc.201100155>
• Altmann Karl-Heinz, Gaugaz Fabienne Z., Schiess Raphael: Diversity through semisynthesis: the chemistry and biological activity of semisynthetic epothilone derivatives. Mol Divers 2011, 15, 383. <http://dx.doi.org/10.1007/s11030-010-9291-0>
• Shibue Taku, Okamoto Iwao, Morita Nobuyoshi, Morita Hiroshi, Hirasawa Yusuke, Hosoya Takahiro, Tamura Osamu: Synthesis and biological evaluation of tubulysin D analogs related to stereoisomers of tubuvaline. Biorg Med Chem Lett 2011, 21, 431. <http://dx.doi.org/10.1016/j.bmcl.2010.10.118>
• Vlahov Iontcho R., Wang Yu, Vetzel Marilynn, Hahn Spencer, Kleindl Paul J., Reddy Joseph A., Leamon Christopher P.: Acid mediated formation of an N-acyliminium ion from tubulysins: A new methodology for the synthesis of natural tubulysins and their analogs. Bioog Med Chem Lett 2011, 21, 6778. <http://dx.doi.org/10.1016/j.bmcl.2011.09.041>
• Shibue Taku, Hirai Toshihiro, Okamoto Iwao, Morita Nobuyoshi, Masu Hyuma, Azumaya Isao, Tamura Osamu: Total Syntheses of Tubulysins. Chem Eur J 2010, 16, 11678. <http://dx.doi.org/10.1002/chem.201000963>
• Weissman Kira J., Müller Rolf: A brief tour of myxobacterial secondary metabolism. biorg med chem 2009, 17, 2121. <http://dx.doi.org/10.1016/j.bmc.2008.11.025>
• Shibue Taku, Hirai Toshihiro, Okamoto Iwao, Morita Nobuyoshi, Masu Hyuma, Azumaya Isao, Tamura Osamu: Stereoselective synthesis of tubuvaline methyl ester and tubuphenylalanine, components of tubulysins, tubulin polymerization inhibitors. Tetrahetron Lett 2009, 50, 3845. <http://dx.doi.org/10.1016/j.tetlet.2009.04.046>
• Patterson Andrew W., Peltier Hillary M., Sasse Florenz, Ellman Jonathan A.: Design, Synthesis, and Biological Properties of Highly Potent Tubulysin D Analogues. Chem Eur J 2007, 13, 9534. <http://dx.doi.org/10.1002/chem.200701057>
• Wang Zhiyong, McPherson Peter A., Raccor Brianne S., Balachandran Raghavan, Zhu Guangyu, Day Billy W., Vogt Andreas, Wipf Peter: Structure?activity and High-content Imaging Analyses of Novel Tubulysins. Chem Biol Drug Design 2007, 70, 75. <http://dx.doi.org/10.1111/j.1747-0285.2007.00541.x>
• Mihovilovic Marko D., Grötzl Birgit, Kandioller Wolfgang, Snajdrova Radka, Muskotál Adél, Bianchi Dario A., Stanetty Peter: Facile Synthesis and Ring-Opening Cross Metathesis of Carbo- and Heterocyclic Bicyclo[3.2.1]oct-6-en-3-ones Using Gaseous Olefinic Reaction Partners. Adv Synth Catal 2006, 348, 463. <http://dx.doi.org/10.1002/adsc.200505375>
• Dömling Alexander, Beck Barbara, Eichelberger Uwe, Sakamuri Sukumar, Menon Sanjay, Chen Quin-Zene, Lu Yingchun, Wessjohann Ludger A.: Total Synthesis of Tubulysin U and V. Angew Chem 2006, 118, 7393. <http://dx.doi.org/10.1002/ange.200601259>
• Dömling Alexander, Beck Barbara, Eichelberger Uwe, Sakamuri Sukumar, Menon Sanjay, Chen Quin-Zene, Lu Yingchun, Wessjohann Ludger A.: Total Synthesis of Tubulysin U and V. Angew Chem Int Ed 2006, 45, 7235. <http://dx.doi.org/10.1002/anie.200601259>
• Khalil Mohamed W., Sasse Florenz, Lünsdorf Heinrich, Elnakady Yasser A., Reichenbach Hans: Mechanism of Action of Tubulysin, an Antimitotic Peptide from Myxobacteria. Chem Eur J of Chem Bio 2006, 7, 678. <http://dx.doi.org/10.1002/cbic.200500421>
• Neri Dario, Fossati Giacomo, Zanda Matteo: Efforts toward the Total Synthesis of Tubulysins: New Hopes for a More Effective Targeted Drug Delivery to Tumors. ChemMedChem 2006, 1, 175. <http://dx.doi.org/10.1002/cmdc.200500043>
• Palacios Francisco, Herrán Esther, Alonso Concepción, Rubiales Gloria: Regioselective cycloaddition of 3-azatrienes with enamines. Synthesis of pyridines derived from β-aminoacids. Tetrahedron 2006, 62, 7661. <http://dx.doi.org/10.1016/j.tet.2006.05.073>
• Palacios Francisco, Alonso Concepción, Rodríguez Marta, Martínez de Marigorta Eduardo, Rubiales Gloria: Preparation of 3-(Fluoroalkyl)-2-azadienes and Its Application in the Synthesis of (Fluoroalkyl)isoquinoline and -pyridine Derivatives. Eur J Org Chem 2005, 2005, 1795. <http://dx.doi.org/10.1002/ejoc.200400770>
• Friestad Gregory K.: ChiralN-Acylhydrazones: Versatile Imino Acceptors for Asymmetric Amine Synthesis. Eur J Org Chem 2005, 2005, 3157. <http://dx.doi.org/10.1002/ejoc.200500232>
• Herndon James W.: The chemistry of the carbon-transition metal double and triple bond: annual survey covering the year 2003. Coord Chem Rev - 2005, 249, 999. <http://dx.doi.org/10.1016/j.ccr.2004.10.009>
• Palacios Francisco, Alonso Concepción, Rubiales Gloria, Villegas Maite: Aza-Wittig reaction of fluoroalkylated N-vinylic phosphazenes with carbonyl compounds. Usefulness of 2-azadienes for the preparation of fluoroalkyl pyridine derivatives. Tetrahedron 2005, 61, 2779. <http://dx.doi.org/10.1016/j.tet.2005.01.080>
• Butler Mark S.: Natural products to drugs: natural product derived compounds in clinical trials. Nat Prod Rep 2005, 22, 162. <http://dx.doi.org/10.1039/b402985m>
• Wipf Peter, Takada Takeshi, Rishel Michael J.: Synthesis of the Tubuvaline-Tubuphenylalanine (Tuv-Tup) Fragment of Tubulysin. Org Lett 2004, 6, 4057. <http://dx.doi.org/10.1021/ol048252i>
• Hofle G., Glaser N., Leibold T., Karama U., Sasse F., Steinmetz H.: Semisynthesis and Degradation of the Tubulin Inhibitors Epothilone and Tubulysin. ChemInform 2003, 34. <http://dx.doi.org/10.1002/chin.200342285>
• Gerth Klaus, Pradella Silke, Perlova Olena, Beyer Stefan, Müller Rolf: Myxobacteria: proficient producers of novel natural products with various biological activities—past and future biotechnological aspects with the focus on the genus Sorangium. J Biotechnol 2003, 106, 233. <http://dx.doi.org/10.1016/j.jbiotec.2003.07.015>