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Pure Appl. Chem., 2003, Vol. 75, No. 2-3, pp. 143-155

Inspirations from nature. New reactions, new therapeutic leads, and new drug delivery systems

P. A. Wender*, J. L. Baryza, S. E. Brenner, M. O. Clarke, G. G. Gamber, J. C. Horan, T. C. Jessop, Cindy Kan, K. Pattabiraman and T. J. Williams

Department of Chemistry, Stanford University, Stanford, CA 94305, USA

Abstract: Studies in our laboratory focus on problems in chemistry (new reactions and synthesis), biology (novel modes of action), and medicine (new therapeutic leads and drug delivery systems). These interconnected and often synergistic activities are inspired by an interest in novel structures, frequently from nature, that possess unique modes of action and significant clinical potential. Described herein are some examples of recent work from our laboratory that have led to new transition metal-catalyzed reactions, a new and remarkably potent therapeutic lead, and new drug delivery systems that are in clinical trials.