Pure and Applied Chemistry

Manufactured chemicals are essential to the vast array of goods and services that contribute to modern life. Their benefits are innumerable, and society is entirely dependent upon them. At the same time, there is an increasing awareness of the concept of environmental impacts. The challenge is to achieve the appropriate balance between the benefits and risks from chemicals, so that we all may enjoy the benefits of chemicals without significant detriment to current and future human and wildlife health. Ecological risk assessment is the mechanism that allows potential environmental chemical exposure to be benchmarked against hazardous properties so that risk is acceptable and environmental health is not impaired. Chemical management decisions based on such assessments are said to be risk-based. Within the context of environmental risk assessment practice for endocrine disruption, industry would support a position that:

To help address uncertainty surrounding the risk from Endocrine Active Substances (EAS) to wildlife, the chemical industry -- via the Long-Range Research Initiative (LRI) -- has implemented a research program aimed at identifying and addressing knowledge gaps and establishing internationally harmonized testing methodologies in cooperation with other stakeholders. Details of individual projects within the current LRI research program are presented.