CrossRef enabled

PAC Archives

Archive →

Pure Appl. Chem., 2003, Vol. 75, No. 11-12, pp. 2023-2038

Male reproductive disorders and the role of endocrine disruption: Advances in understanding and identification of areas for future research

R. M. Sharpe and N. E. Skakkebaek

MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The University of Edinburgh Academic Centre, 49 Little France Crescent, Old Dalkeith Road, Edinburgh EH16 4SB, UK; University Department of Growth & Reproduction, Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen OE,


CrossRef Cited-by theme picture

CrossRef Cited-by Linking

  • Ouellette Julianne, dos Santos Silvia Cristina Cunha, Lépine François, Juteau Pierre, Déziel Eric, Villemur Richard: High absorption of endocrine disruptors by Hytrel: towards the development of a two-phase partitioning bioreactor. J. Chem. Technol. Biotechnol. 2013, 88, 119. <>
  • Béni Zoltán, Háda Viktor, Varga Emese, Mahó Sándor, Aranyi Antal, Szántay Csaba: New oxidative decomposition mechanism of estradiol through the structural characterization of a minute impurity and its degradants. Journal of Pharmaceutical and Biomedical Analysis 2013, 78-79, 183. <>
  • D'Haese Arnout, Le-Clech Pierre, Van Nevel Sam, Verbeken Kim, Cornelissen Emile R., Khan Stuart J., Verliefde Arne R.D.: Trace organic solutes in closed-loop forward osmosis applications: Influence of membrane fouling and modeling of solute build-up. Water Research 2013, 47, 5232. <>
  • Mortimer D., Barratt C. L. R., Bjorndahl L., de Jager C., Jequier A. M., Muller C. H.: What should it take to describe a substance or product as 'sperm-safe'. Human Reproduction Update 2013, 19, i1. <>
  • Plotan Monika, Elliott Christopher T., Oplatowska Michalina, Connolly Lisa: Validation and application of reporter gene assays for the determination of estrogenic and androgenic endocrine disruptor activity in sport supplements. Anal Bioanal Chem 2012, 403, 3057. <>
  • Zhao Yan, Ao Hong, Chen Li, Sottas Chantal M., Ge Ren-shan, Li Luxi, Zhang Yunhui: Mono-(2-ethylhexyl) phthalate affects the steroidogenesis in rat Leydig cells through provoking ROS perturbation. Toxicology in Vitro 2012, 26, 950. <>
  • Auharek S. A., Lara N. L. M., Avelar G. F., Sharpe R. M., França L. R.: Effects of inducible nitric oxide synthase (iNOS) deficiency in mice on Sertoli cell proliferation and perinatal testis development. International Journal of Andrology 2012, 35, 741. <>
  • Wittassek Matthias, Koch Holger Martin, Angerer Jürgen, Brüning Thomas: Assessing exposure to phthalates - The human biomonitoring approach. Mol Nutr Food Res 2011, 55, 7. <>
  • Plotan Monika, Elliott Christopher T., Scippo Marie Louise, Muller Marc, Antignac Jean-Philippe, Malone Edward, Bovee Toine F.H., Mitchell Samuel, Connolly Lisa: The application of reporter gene assays for the detection of endocrine disruptors in sport supplements. Analytica Chimica Acta 2011, 700, 34. <>
  • Koch Holger M., Wittassek Matthias, Brüning Thomas, Angerer Jürgen, Heudorf Ursel: Exposure to phthalates in 5–6 years old primary school starters in Germany—A human biomonitoring study and a cumulative risk assessment. Int J Hyg Environ Health 2011, 214, 188. <>
  • Pathirana I.N., Kawate N., Tsuji M., Takahashi M., Hatoya S., Inaba T., Tamada H.: In vitro effects of estradiol-17β, monobutyl phthalate and mono-(2-ethylhexyl) phthalate on the secretion of testosterone and insulin-like peptide 3 by interstitial cells of scrotal and retained testes in dogs. Theriogenology 2011, 76, 1227. <>
  • Sonne Christian: Health effects from long-range transported contaminants in Arctic top predators: An integrated review based on studies of polar bears and relevant model species. Environ Int 2010, 36, 461. <>
  • Paliwal Preeti, Sharma Arundhati, Sahoo Jayaprakash, Ammini Ariachery Chinamma: An unusual association of hypospadias with partial deletion of chromosome 1q. Fertil Steril 2010, 93, 2413.e11. <>
  • Rhind S. M., Evans N. P., Bellingham M., Sharpe R. M., Cotinot C., Mandon-Pepin B., Loup B., Sinclair K. D., Lea R. G., Pocar P.: Effects of environmental pollutants on the reproduction and welfare of ruminants. ANM 2010, 4, 1227. <>
  • Burkhardt-Holm Patricia: Endocrine Disruptors and Water Quality: A State-of-the-Art Review. Int J Water Res Dev 2010, 26, 477. <>
  • Barnhoorn I.E.J., Bornman M.S., Jansen van Rensburg C., Bouwman H.: DDT residues in water, sediment, domestic and indigenous biota from a currently DDT-sprayed area. Chemosphere 2009, 77, 1236. <>
  • Sonne Christian, Gustavson Kim, Rigét Frank F., Dietz Rune, Birkved Morten, Letcher Robert J., Bossi Rossana, Vorkamp Katrin, Born Erik W., Petersen Gitte: Reproductive performance in East Greenland polar bears (Ursus maritimus) may be affected by organohalogen contaminants as shown by physiologically-based pharmacokinetic (PBPK) modelling. Chemosphere 2009, 77, 1558. <>
  • Burger Joanna: Stakeholder Involvement in Indicator Selection: Case Studies and Levels of Participation. Env Bioindicators 2009, 4, 170. <>
  • McKinnell C., Mitchell R. T., Walker M., Morris K., Kelnar C. J.H., Wallace W. H., Sharpe R. M.: Effect of fetal or neonatal exposure to monobutyl phthalate (MBP) on testicular development and function in the marmoset. Hum Reprod 2009, 24, 2244. <>
  • Sonne Christian, Dietz Rune, Born Erik W., Leifsson Pall S., Andersen Steen: Is there a link between hypospadias and organochlorine exposure in East Greenland sledge dogs (Canis familiaris)?. Ecotoxicological and Environmental Safety 2008, 69, 391. <>
  • Woodruff Tracey J., Carlson Alison, Schwartz Jackie M., Giudice Linda C.: Proceedings of the Summit on Environmental Challenges to Reproductive Health and Fertility: executive summary. Fertil Steril 2008, 89, 281. <>
  • Sharpe Richard M., Skakkebaek Niels E.: Testicular dysgenesis syndrome: mechanistic insights and potential new downstream effects. Fertil Steril 2008, 89, e33. <>
  • Woodruff Tracey J., Carlson Alison, Schwartz Jackie M., Giudice Linda C.: Proceedings of the Summit on Environmental Challenges to Reproductive Health and Fertility: executive summary. Fertil Steril 2008, 89, e1. <>
  • Brown K. H., Schultz I. R., Cloud J. G., Nagler J. J.: Aneuploid sperm formation in rainbow trout exposed to the environmental estrogen 17 -ethynylestradiol. Proceedings of the National Academy of Sciences 2008, 105, 19786. <>
  • Phillips Karen P., Tanphaichitr Nongnuj: Human Exposure to Endocrine Disrupters and Semen Quality. Journal of Toxicology and Environmental Health, Part B 2008, 11, 188. <>
  • Hutchison Gary R., Sharpe Richard M., Mahood I. Kim, Jobling Matt, Walker Marion, McKinnell Chris, Mason J. Ian, Scott Hayley M.: The origins and time of appearance of focal testicular dysgenesis in an animal model of testicular dysgenesis syndrome: evidence for delayed testis development?. Int J Androl 2008, 31, 103. <>
  • Welsh Michelle, Saunders Philippa T.K., Fisken Mark, Scott Hayley M., Hutchison Gary R., Smith Lee B., Sharpe Richard M.: Identification in rats of a programming window for reproductive tract masculinization, disruption of which leads to hypospadias and cryptorchidism. J Clin Invest 2008, 118, 1479. <>
  • Martin Olwenn V., Shialis Tassos, Lester John N., Scrimshaw Mark D., Boobis Alan R., Voulvoulis Nikolaos: Testicular Dysgenesis Syndrome and the Estrogen Hypothesis: A Quantitative Meta-Analysis. Environ Health Perspect 2007, 116, 149. <>
  • Bay Katrine, Asklund Camilla, Skakkebaek Niels E., Andersson Anna-Maria: Testicular dysgenesis syndrome: possible role of endocrine disrupters. Best Pract Res Clin Endocrinol Metab 2006, 20, 77. <>
  • Sharpe Richard M.: Pathways of endocrine disruption during male sexual differentiation and masculinisation. Best Pract Res Clin Endocrinol Metab 2006, 20, 91. <>
  • Skakkebaek Niels E., Jorgensen Niels, Main Katharina M., Meyts Ewa Rajpert-De, Leffers Henrik, Andersson Anna-Maria, Juul Anders, Carlsen Elisabeth, Mortensen Gerda Krog, Jensen Tina Kold: Is human fecundity declining?. Int J Androl 2006, 29, 2. <>
  • MAHOOD I. KIM, MCKINNELL CHRIS, WALKER MARION, HALLMARK NINA, SCOTT HAYLEY, FISHER JANE S., RIVAS ANA, HARTUNG STEFAN, IVELL RICHARD, MASON J. IAN: Cellular origins of testicular dysgenesis in rats exposed in utero to di(n-butyl) phthalate. Int J Androl 2006, 29, 148. <>
  • Spjuth Linda, Ljungvall Karl, Saravia Fernando, Lundeheim Nils, Magnusson Ulf, Hulten Fredrik, Rodriguez-Martinez Heriberto: Does exposure to di(2-ethylhexyl) phthalate in pre-pubertal boars affect semen quality post-puberty?. Int J Androl 2006, 29, 534. <>
  • Damgaard Ida N., Skakkebæk Niels E., Toppari Jorma, Virtanen Helena E., Shen Heqing, Schramm Karl-Werner, Petersen Jørgen H., Jensen Tina K., Main Katharina M.: Persistent Pesticides in Human Breast Milk and Cryptorchidism. Environ Health Perspect 2006, 114, 1133. <>
  • Hallmark Nina, Walker Marion, McKinnell Chris, Mahood I. Kim, Scott Hayley, Bayne Rosemary, Coutts Shiona, Anderson Richard A., Greig Irene, Morris Keith: Effects of Monobutyl and Di(n-butyl) Phthalate in Vitro on Steroidogenesis and Leydig Cell Aggregation in Fetal Testis Explants from the Rat: Comparison with Effects in Vivo in the Fetal Rat and Neonatal Marmoset and in Vitro in the Human. Environ Health Perspect 2006, 115, 390. <>
  • Paul Catriona, Rhind Stewart M., Kyle Carol E., Scott Hayley, McKinnell Chris, Sharpe Richard M.: Cellular and Hormonal Disruption of Fetal Testis Development in Sheep Reared on Pasture Treated with Sewage Sludge. Environ Health Perspect 2005, 113, 1580. <>
  • Oskam I. C, Lyche J. L, Krogenaes A., Thomassen R., Skaare J. U, Wiger R., Dahl E., Sweeney T., Stien A., Ropstad E.: Effects of long-term maternal exposure to low doses of PCB126 and PCB153 on the reproductive system and related hormones of young male goats. Reproduction 2005, 130, 731. <>