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Pure Appl. Chem., 2003, Vol. 75, No. 10, pp. 1443-1451

Birch reduction and its application in the total synthesis of natural products

G. S. R. Subba Rao

Department of Organic Chemistry, Indian Institute of Science, Bangalore 560 012, India

Abstract: The unique availability of substituted cyclohexa-1,4- and 1,3-dienes, notably enol ethers, from Birch reduction of anisoles, permits many novel synthetic reactions of general utility. The total synthesis of several natural products derived from polyketides have been accomplished using a Diels–Alder and Alder–Rickert process. The strategies of the synthesis are discussed.