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Pure Appl. Chem., 2002, Vol. 74, No. 8, pp. 1469-1477

Role of gene regulation in the anticancer activity of carotenoids

Yoav Sharoni*, Michael Danilenko, Shlomo Walfisch, Hadar Amir, Amit Nahum, Anat Ben-Dor, Keren Hirsch, Marina Khanin, Michael Steiner, Lilach Agemy, Gabriel Zango and Joseph Levy

Department of Clinical Biochemistry, Faculty of Health Sciences, Ben-Gurion University of the Negev and Soroka Medical Center of Kupat Holim, Beer-Sheva, Israel

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  • Bolhassani Azam, Khavari Afshin, Bathaie S. Zahra: Saffron and natural carotenoids: Biochemical activities and anti-tumor effects. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 2014, 1845, 20. <>
  • Bahieldin Ahmed, Gadalla Nour O., Al-Garni Saleh M., Almehdar Hussein, Noor Samah, Hassan Sabah M., Shokry Ahmed M., Sabir Jamal S.M., Murata Norio: Efficient production of lycopene in Saccharomyces cerevisiae by expression of synthetic crt genes from a plasmid harboring the ADH2 promoter. Plasmid 2014, 72, 18. <>
  • Zhang Xia, Zhao Wen-en, Hu Liqiang, Zhao Lei, Huang Jinyong: Carotenoids inhibit proliferation and regulate expression of peroxisome proliferators-activated receptor gamma (PPAR��) in K562 cancer cells. Archives of Biochemistry and Biophysics 2011, 512, 96. <>
  • Tan Hsueh-Li, Thomas-Ahner Jennifer M., Grainger Elizabeth M., Wan Lei, Francis David M., Schwartz Steven J., Erdman John W., Clinton Steven K.: Tomato-based food products for prostate cancer prevention: what have we learned?. Cancer Metast Rev 2010, 29, 553. <>
  • Perera Conrad O., Yen Gan Mei: Functional Properties of Carotenoids in Human Health. Int J Food Prop 2007, 10, 201. <>
  • Barba A.I. Olives, Hurtado M. Cámara, Mata M.C. Sánchez, Ruiz V. Fernández, Tejada M. López Sáenz de: Application of a UV–vis detection-HPLC method for a rapid determination of lycopene and β-carotene in vegetables. Food Chem 2006, 95, 328. <>
  • McGraw Kevin J., Crino Ondi L., Medina-Jerez William, Nolan Paul M.: Effect of Dietary Carotenoid Supplementation on Food Intake and Immune Function in a Songbird with no Carotenoid Coloration. Ethology 2006, 112, 1209. <>
  • McGraw Kevin J., Klasing Kirk C.: Carotenoids, Immunity, and Integumentary Coloration in Red Junglefowl (Gallus gallus) (Carotenoides, Inmunidad y Coloración Integumentaria en Gallus gallus). The Auk 2006, 123, 1161. <>
  • McGraw K. J., Adkins-Regan E., Parker R. S.: Maternally derived carotenoid pigments affect offspring survival, sex ratio, and sexual attractiveness in a colorful songbird. Naturwiss 2005, 92, 375. <>
  • Palozza Paola, Serini Simona, Di Nicuolo Fiorella, Calviello Gabriella: Modulation of apoptotic signalling by carotenoids in cancer cells. Archives of Biochemistry and Biophysics 2004, 430, 104. <>
  • Palozza Paola, Serini Simona, Di Nicuolo Fiorella, Piccioni Elisabetta, Calviello Gabriella: Prooxidant effects of β-carotene in cultured cells. Molec Aspects Med 2003, 24, 353. <>