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Pure Appl. Chem., 2002, Vol. 74, No. 8, pp. 1349-1357

http://dx.doi.org/10.1351/pac200274081349

Development of a general process for the synthesis of highly substituted imidazoles

Joseph Sisko* and Mark Mellinger

Synthetic Chemistry, GlaxoSmithKline, 709 Swedeland Road, P.O. Box 1539, UW2820, King of Prussia, PA 19406-0939, USA

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  • Kannan V., Sreekumar K.: Clay supported titanium catalyst for the solvent free synthesis of tetrasubstituted imidazoles and benzimidazoles. Journal of Molecular Catalysis A: Chemical 2013, 376, 34. <http://dx.doi.org/10.1016/j.molcata.2013.04.004>
  • Akkurt Mehmet, Mohamed Shaaban K., Singh Kuldip, Marzouk Adel A., Abdelhamid Antar A.: 2-(2,6-Dichlorophenyl)-1-pentyl-4,5-diphenyl-1H-imidazole. Acta Crystallogr E Struct Rep Online 2013, 69, o846. <http://dx.doi.org/10.1107/S1600536813011446>
  • Mohamed Shaaban K., Akkurt Mehmet, Marzouk Adel A., Abdelhamid Antar A., Santoyo-Gonzalez Francisco: Prop-2-en-1-yl 4-(4,5-diphenyl-1H-imidazol-2-yl)benzoate. Acta Crystallogr E Struct Rep Online 2013, 69, o1105. <http://dx.doi.org/10.1107/S160053681301619X>
  • Xu Zhigang, Shaw Arthur Y., Nichol Gary S., Cappelli Alexandra P., Hulme Christopher: Applications of ortho-phenylisonitrile and ortho-N-Boc aniline for the two-step preparation of novel bis-heterocyclic chemotypes. Mol Divers 2012, 16, 607. <http://dx.doi.org/10.1007/s11030-012-9374-1>
  • Dömling Alexander, Wang Wei, Wang Kan: Chemistry and Biology Of Multicomponent Reactions. Chem. Rev. 2012, 112, 3083. <http://dx.doi.org/10.1021/cr100233r>
  • Azizi Najmadin, Dado Nairreh, Amiri Alireza Khajeh: Highly efficient one-pot synthesis of trisubstituted imidazoles under catalyst-free conditions. Can J of Chem 2012, 90, 195. <http://dx.doi.org/10.1139/v11-141>
  • Rafiee Ezzat, Mahdavi Houri, Joshaghani Mohammad: Supported heteropoly acids offering strong option for efficient and cleaner processing for the synthesis of imidazole derivatives under solvent-free condition. Mol Divers 2011, 15, 125. <http://dx.doi.org/10.1007/s11030-009-9213-1>
  • Sharma Gyanendra Kumar, Pathak Devender: Microwave-Assisted, Solvent-Free and Parallel Synthesis of Some Novel Substituted Imidazoles of Biological Interest. Chem Pharm Bull 2010, 58, 375. <http://dx.doi.org/10.1248/cpb.58.375>
  • Kumar B. R. Prashantha, Sharma Gyanendra Kumar, Srinath S., Noor Mohamed, Suresh B., Srinivasa B. R.: Microwave-assisted, solvent-free, parallel syntheses and elucidation of reaction mechanism for the formation of some novel tetraaryl imidazoles of biological interest. J Heterocyclic Chem 2009, 46, 278. <http://dx.doi.org/10.1002/jhet.68>
  • Fulwa Vijendra Kumar, Sahu Rojalin, Jena Himanshu Sekhar, Manivannan Vadivelu: Novel synthesis of 2,4-bis(2-pyridyl)-5-(pyridyl)imidazoles and formation of N-(3-(pyridyl)imidazo[1,5-a]pyridine)picolinamidines: nitrogen-rich ligands. Tetrahetron Lett 2009, 50, 6264. <http://dx.doi.org/10.1016/j.tetlet.2009.09.002>
  • Heravi Majid M., Derikvand Fatemeh, Haghighi Masoumeh: Highly Efficient, Four Component, One-pot Synthesis of Tetrasubstituted Imidazoles Using a Catalytic Amount of FeCl3 · 6H2O. Monatshefte für Chemie 2008, 139, 31. <http://dx.doi.org/10.1007/s00706-007-0736-9>
  • Kantevari Srinivas, Vuppalapati Srinivasu V.N., Biradar Dhanraj O., Nagarapu Lingaiah: Highly efficient, one-pot, solvent-free synthesis of tetrasubstituted imidazoles using HClO4–SiO2 as novel heterogeneous catalyst. Journal of Molecular Catalysis A 2007, 266, 109. <http://dx.doi.org/10.1016/j.molcata.2006.10.048>
  • Bellina Fabio, Cauteruccio Silvia, Rossi Renzo: Synthesis and biological activity of vicinal diaryl-substituted 1H-imidazoles. Tetrahedron 2007, 63, 4571. <http://dx.doi.org/10.1016/j.tet.2007.02.075>
  • Beck Barbara, Leppert Christian A., Mueller Bernhard K., Dömling Alexander: Discovery Of Pyrroloimidazoles As Agents Stimulating Neurite Outgrowth. QSAR Comb Sci 2006, 25, 527. <http://dx.doi.org/10.1002/qsar.200540300>