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Pure Appl. Chem., 2002, Vol. 74, No. 4, pp. 511-517

Biodiversity: A wonderful source of exciting new pharmacophores. Further to a new theory of memory

Atta-ur-Rahman and M. Iqbal Choudhary

H. E. J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi-75270, Pakistan

Abstract: The diverse biological resources in nature are vast factories of chemical diversity. With the recent advances in the biological and chemical sciences it is now easier than ever to explore the potential uses of immense biological resources in a sustainable manner. Our investigations focused on the bioprospecting of both terrestrial and marine organisms have led to the discovery of a number of interesting chemical compounds. The discovery of a new class of cholinesterase, α-glucosidase and phosphodiesterase I inhibitors, several new antioxidants, and other classes of bioactive natural products is presented. The theory of the chemical basis of memory through hydrogen bonding in the brain is further elaborated.