Pure Appl. Chem., 2002, Vol. 74, No. 12, pp. 2253-2257
http://dx.doi.org/10.1351/pac200274122253
Advances in biocatalytic synthesis. Enzyme-triggered asymmetric cascade reactions
Abstract:
Organic compounds can be transformed through enzyme-triggered domino (or cascade) reactions via several (inseparable) consecutive steps in an asymmetric fashion to yield nonracemic products. Despite the fact that these sequences often involve the occurrence of highly reactive unstable intermediates, the overall efficiency of these processes can be high, provided that the reaction rates of the individual steps match each other in order to minimize side reactions.