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Pure Appl. Chem., 2002, Vol. 74, No. 1, pp. 135-142

Curiosity and simplicity in the invention and discovery of new metal-mediated reactions for organic synthesis

William B. Motherwell

Department of Chemistry, Christopher Ingold Laboratories, University College London, 20 Gordon Street, London, WC1H OAJ, UK

Abstract: Two organometallic themes of current interest are presented. The scope and generality of the reductive deoxygenation of carbonyl compounds to organozinc carbenoids using zinc in combination with a silicon electrophile is discussed. Alkoxycyclopropanation can be achieved using orthoformates as substrates. Preliminary observations on the development of a rhodium-catalyzed tandem hydrosilylation­intramolecular aldol sequence are discussed.