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Pure Appl. Chem., 2002, Vol. 74, No. 1, pp. 37-42

http://dx.doi.org/10.1351/pac200274010037

Copper-mediated asymmetric transformations

Alexandre Alexakis

Department of Organic Chemistry, University of Geneva, 30 quai Ernest Ansermet, Geneva, CH-1211, Switzerland

Abstract: Copper-catalyzed reactions include the enantioselective conjugate addition and the SN2¢ substitution. We describe the genesis of these reactions, the choice of the primary organometallic reagent, and our studies on finding new Michael acceptors and new ligands. We also report on the use of the zinc enolate generated upon conjugate addition.