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Pure Appl. Chem., 2001, Vol. 73, No. 9, pp. 1499-1509

http://dx.doi.org/10.1351/pac200173091499

Opioid and sigma receptor studies. New developments in the design of selective sigma ligands

Giuseppe Ronsisvalle1, Agostino Marrazzo1, Orazio Prezzavento1, Alfredo Cagnotto2, Tiziana Mennini2, Carmela Parenti1 and Giovanna M. Scoto1

1 Department of Pharmaceutical Sciences, University of Catania, Viale Andrea Doria, 6, 95125 Catania
2 Department of Molecular Biochemistry and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milano, Italy

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  • Lan Yu, Chen Yin, Xu Xiangqing, Qiu Yinli, Liu Shicheng, Liu Xin, Liu Bi-Feng, Zhang Guisen: Synthesis and biological evaluation of a novel sigma-1 receptor antagonist based on 3,4-dihydro-2(1H)-quinolinone scaffold as a potential analgesic. European Journal of Medicinal Chemistry 2014, 79, 216. <http://dx.doi.org/10.1016/j.ejmech.2014.04.019>
  • Ashford Mark E., Nguyen Vu H., Greguric Ivan, Pham Tien Q., Keller Paul A., Katsifis Andrew: Synthesis and in vitro evaluation of tetrahydroisoquinolines with pendent aromatics as sigma-2 (σ2) selective ligands. Org. Biomol. Chem. 2014, 12, 783. <http://dx.doi.org/10.1039/c3ob42254b>
  • Sánchez-Fernández Cristina, Nieto Francisco Rafael, González-Cano Rafael, Artacho-Cordón Antonia, Romero Lucía, Montilla-García Ángeles, Zamanillo Daniel, Baeyens José Manuel, Entrena José Manuel, Cobos Enrique José: Potentiation of morphine-induced mechanical antinociception by σ1 receptor inhibition: Role of peripheral σ1 receptors. Neuropharmacology 2013, 70, 348. <http://dx.doi.org/10.1016/j.neuropharm.2013.03.002>
  • Díaz José Luis, Christmann Ute, Fernández Ariadna, Luengo Mónica, Bordas Magda, Enrech Raquel, Carro Mónica, Pascual Rosalia, Burgueño Javier, Merlos Manuel, Benet-Buchholz Jordi, Cerón-Bertran Jordi, Ramírez Jesús, Reinoso Raquel F., Fernández de Henestrosa Antonio R., Vela José Miguel, Almansa Carmen: Synthesis and Biological Evaluation of a New Series of Hexahydro-2H-pyrano[3,2-c]quinolines as Novel Selective σ1 Receptor Ligands. J. Med. Chem. 2013, 56, 3656. <http://dx.doi.org/10.1021/jm400181k>
  • Díaz José Luis, Cuberes Rosa, Berrocal Joana, Contijoch Montserrat, Christmann Ute, Fernández Ariadna, Port Adriana, Holenz Jörg, Buschmann Helmut, Laggner Christian, Serafini Maria Teresa, Burgueño Javier, Zamanillo Daniel, Merlos Manuel, Vela José Miguel, Almansa Carmen: Synthesis and Biological Evaluation of the 1-Arylpyrazole Class of σ1 Receptor Antagonists: Identification of 4-{2-[5-Methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yloxy]ethyl}morpholine (S1RA, E-52862). J. Med. Chem. 2012, 55, 8211. <http://dx.doi.org/10.1021/jm3007323>
  • Romero L, Zamanillo D, Nadal X, Sánchez-Arroyos R, Rivera-Arconada I, Dordal A, Montero A, Muro A, Bura A, Segalés C, Laloya M, Hernández E, Portillo-Salido E, Escriche M, Codony X, Encina G, Burgueño J, Merlos M, Baeyens JM, Giraldo J, López-García JA, Maldonado R, Plata-Salamán CR, Vela JM: Pharmacological properties of S1RA, a new sigma-1 receptor antagonist that inhibits neuropathic pain and activity-induced spinal sensitization. British Journal of Pharmacology 2012, 166, 2289. <http://dx.doi.org/10.1111/j.1476-5381.2012.01942.x>
  • Prezzavento Orazio, Parenti Carmela, Marrazzo Agostino, Ronsisvalle Simone, Vittorio Franco, Aricò Giuseppina, Scoto Giovanna M., Ronsisvalle Giuseppe: A new sigma ligand, (±)-PPCC, antagonizes kappa opioid receptor-mediated antinociceptive effect. Life Sci Oxford 2008, 82, 549. <http://dx.doi.org/10.1016/j.lfs.2007.11.032>
  • Marrazzo Agostino, Parenti Carmela, Scavo Valentina, Ronsisvalle Simone, Maria Scoto Giovanna, Ronsisvalle Giuseppe: In vivo evaluation of (+)-MR200 as a new selective sigma ligand modulating MOP, DOP and KOP supraspinal analgesia. Life Sci Oxford 2006, 78, 2449. <http://dx.doi.org/10.1016/j.lfs.2005.10.005>