Pure Appl. Chem., 2001, Vol. 73, No. 7, pp. 1103-1111
http://dx.doi.org/10.1351/pac200173071103
New methods for high-throughput synthesis
Abstract:
New methodologies for library synthesis have been developed. They are based on new carboncarbon bond-formation reactions in the solid-phase and organic synthesis using polymer-supported catalysts. We have immobilized alkyl glyoxylate equivalents onto resins and prepared novel polymer-supported imines. We have also developed unprecedented polymer-supported catalysts such as microencapsulated scandium trifluoromethanesulfonate [MC Sc(OTf)3], osmium tetroxide (MC OsO4), and palladium triphenylphosphine [MC Pd(PPh3)] for high-throughput synthesis.