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Pure Appl. Chem., 2001, Vol. 73, No. 7, pp. 1033-1039

Integrating natural product synthesis and combinatorial chemistry

A. Ganesan

Department of Chemistry, University of Southampton, Southampton SO17 1BJ, United Kingdom

Abstract: The fields of natural product total synthesis and combinatorial chemistry have major differences as well as much in common. Unique to combinatorial chemistry is the need to devise rapid and efficient methods for parallel synthesis and purification, while an area of overlap is the targeting of natural product scaffolds for combinatorial libraries. Both these aspects are illustrated with examples from our research.


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