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Pure Appl. Chem., 2001, Vol. 73, No. 3, pp. 623-626

Studies directed toward the preparation of key intermediates for the synthesis of trisporic acids and cassiol

María I. Colombo, Juan Zinczuk, Mirta P. Mischne and Edmundo A. Rúveda*

Instituto de Química Orgánica de Síntesis (CONICET-UNR) Facultad de Ciencias Bioquímicas y Farmacéuticas, Casilla de Correo 991, 2000 Rosario, Argentina

Abstract: An enantioselective synthesis and resolution of the key White intermediate (3) for the synthesis of trisporic acids are described. Attempts to develop a synthetic route toward the antiulcerogenic compound cassiol (2) by an olefination reaction of 3 and an alternative sequence involving a Michael addition followed by an aldol condensation of an open substrate, are also reported.