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Pure Appl. Chem., 2001, Vol. 73, No. 3, pp. 579-582

Chemistry and biotransformations in the Scrophulariaceae family

J. A. Garbarino1*, B. M. Fraga2, M. G. Hernandez2, M. C. Chamy1 and M. Piovano1

1 Departamento de Química, Universidad Técnica Federico Santa María, Casilla 110-V, Valparaíso, Chile
2 Instituto de Productos Naturales y Agrobiología, Tenerife, España

Abstract: One of our research lines has been the chemical studies among Calceolaria species (Scrophulariaceae), from which have been isolated 77 new diterpenes of various skeleton types (labdanes, pimaranes, stemaranes, and stemodanes), all coming from a common bicyclic intermediate, having H-9 and C-20 as a cis relationship and C-11 becomes trans with respect to C-20. Another line of research is bringing out chemical changes on diterpenes obtained from this family, using biological systems as the fungus Giberella fujikuroi and Mucor plumbeus.