CrossRef enabled

PAC Archives

Archive →

Pure Appl. Chem., 2001, Vol. 73, No. 3, pp. 555-560

Bioactive natural products as a potential source of new pharmacophores. A theory of memory

Atta-ur-Rahman and M. Iqbal Choudhary

International Centre for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan

Abstract: The plant kingdom offers a rich source of structural biodiversity in the form of a variety of natural products. Our work on new bioactive compounds from medicinal plants has led to the isolation and structure elucidation of a number of exciting new pharmacophores. Bioassay-guided fractionation has recently led to the discovery of a series of new acetylcholinesterase, urease and a-glucosidase inhibitors, antioxidants and other classes of bioactive compounds, which will be presented. A theory based on hydrogen bonding on the chemical basis of memory storage in the brain is presented.