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Pure Appl. Chem., 2001, Vol. 73, No. 10, pp. 1573-1577

Threading intercalation to double-stranded DNA and the application to DNA sensing. Electrochemical array technique

Makoto Takagi

Department of Applied Chemistry, Faculty of Engineering, Kyushu University, Higashi, Fukuoka, Japan

Abstract: Electrochemical labeling of double-stranded (ds) DNA is achieved by redox-active DNA intercalators. Threading intercalators derived from naphthalenediimide appended with ferrocene reporter group in the side arms are particularly useful for this purpose. This allows a sensitive electrochemical detection of DNA hybridization on an array, providing a great potential for low-cost, high-throughput, and quick DNA screening technique in post-genome study.