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Pure Appl. Chem., 2001, Vol. 73, No. 1, pp. 187-191

Recent progress in the chemistry of multicomponent reactions

Ivar Ugi

Technical University of Munich, Department of Organic Chemistry, Chair 1, Lichtenbergstrasse 4, D-85747 Garching, Germany

Abstract: The chemistry of multicomponent reactions (MCRs) and isocyanides belongs to three periods: In the century 1859­1958, isocyanide chemistry was moderately active and was separate from the classical name reactions of the MCRs. In the next period, isocyanides became well available, and MCRs of isocyanides became the most variable way of forming chemical compounds. The year 1993 began a new era of the formation and investigation of the products and the libraries of the Ugi reaction (U-4CR) and higher MCRs of the isocyanides. This chemistry is primarily accomplished in the industrial search and preparation of new pharmaceutical and plant-protecting products.