Pure and Applied Chemistry

Abstract: By learning how to balance natural resource limitations and pollution prevention with economic growth, green chemistry will become the central science of sustainability. The elimination of persistent pollutants is vital for a sustainable civilization. To achieve this, the most important guiding concept is that the elemental composition of technology should be shifted toward the elemental composition of biochemistry. Oxidation chemistry is currently a prolific producer of persistent pollutants. Many arise from the use of chlorine, hypochlorite, or chlorine dioxide in large-scale oxidation processes. Oxidation chemistry can be greened by replacing these with catalyzed alternatives based on Nature's oxidizing agent, hydrogen peroxide. TAML® (TetraAmidoMacrocyclicLigand) iron catalysts, which were invented at Carnegie Mellon University, are widely patented and are being developed to activate H₂O₂ for commercial applications. TAML activators are water-soluble, easy to use, function well from neutral to basic pH, are not dominated by nonselective Fenton-like reactivity, are straightforward to synthesize, work effectively in minute concentrations, enable peroxide processes to occur at temperatures well below those of the processes targeted for replacement, and are amenable to modification for capturing novel selectivities. TAML activators are "dial-a-lifetime" catalysts: an activator can be chosen exhibiting a lifetime commensurate with the desired task.