Pure Appl. Chem., 2000, Vol. 72, No. 9, pp. 1721-1737
http://dx.doi.org/10.1351/pac200072091721
Oxazoline-N-oxide mediated asymmetric cycloadditions. Recent progress in the stereo-selective syntheses of β-lactones and β-lactams
Abstract:
Camphor-derived oxazoline-N-oxides are versatile dipoles in a new kind of asymmetric [2+3] cycloadditions. Recent applications of this methodology allowed the stereoselective syntheses of several b-lactones natural products such as 1233A and tetrahydrolipstatine. Two formal syntheses of b-lactams antibiotics, b-methyl thienamycin and carpetimycin A, have also been achieved using this type of cycloaddition.