Pure Appl. Chem., 2000, Vol. 72, No. 9, pp. 1705-1708
http://dx.doi.org/10.1351/pac200072091705
New nucleoside analogs, synthesis, and biological properties
Abstract:
In view of the importance of nucleoside analogs as enzyme inhibitors and adenosine receptor (ant)agonists, new adenosine analogs were prepared and their activities studied on adenosine deaminase in vitro and on A1, A2A, and A3 receptors. Particularly useful for the synthesis of new analogs were the applications of the Pd-catalyzed Buchwald reaction and a radical nitration reaction of purine- and 1-deazapurine nucleosides.