Pure Appl. Chem., 2000, Vol. 72, No. 9, pp. 1631-1634
http://dx.doi.org/10.1351/pac200072091631
Total synthesis of herboxidiene, a complex polyketide from Streptomyces species A7847
Abstract:
A formal total synthesis of the polyketide herboxidiene (1) has been achieved by Horner-Wittig coupling of the side-chain fragment 12-epi-(2) with the tetrahydropyran-2-acetic acid derivative (3) followed by desilylation of the resulting triene (19) and hydroxyl-directed mono-epoxidation of the ensuing bis-homoallylic alcohol (20).