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Pure Appl. Chem., 2000, Vol. 72, No. 7, pp. 1373-1380

Green Lewis acid catalysis in organic synthesis

Shū Kobayashi and Kei Manabe

Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan

Abstract: New types of Lewis acids as water-stable catalysts have been developed. Metal salts such as rare earth metal triflates can be used in carbon_carbon bond-forming reactions in aqueous media. These salts can be recovered after the reactions and reused. Furthermore, Lewis acid_surfactant-combined catalysts, which can be used for reactions in water without using any organic solvents, have been also developed. Finally, Lewis acid catalysis in supercritical carbon dioxide has been successfully performed. These investigations will contribute to development of environmentally friendly Lewis acid catalysis.