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Pure Appl. Chem., 1963, Vol. 7, No. 4, pp. 527-538

http://dx.doi.org/10.1351/pac196307040527

The biosynthesis of antibiotics

A. J. Birch

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  • Runguphan Weerawat, O’Connor Sarah E.: Diversification of Monoterpene Indole Alkaloid Analogs through Cross-Coupling. Org. Lett. 2013, 15, 2850. <http://dx.doi.org/10.1021/ol401179k>
  • Franke Jana, Eichner Simone, Zeilinger Carsten, Kirschning Andreas: Targeting heat-shock-protein 90 (Hsp90) by natural products: geldanamycin, a show case in cancer therapy. Nat. Prod. Rep. 2013, 30, 1299. <http://dx.doi.org/10.1039/c3np70012g>
  • Kirschning Andreas, Hahn Frank: Vereinigung von chemischer Synthese und Biosynthese: ein neues Kapitel in der Totalsynthese von Naturstoffen und Naturstoffbibliotheken. Angew. Chem. 2012, 124, 4086. <http://dx.doi.org/10.1002/ange.201107386>
  • Kirschning Andreas, Hahn Frank: Merging Chemical Synthesis and Biosynthesis: A New Chapter in the Total Synthesis of Natural Products and Natural Product Libraries. Angew. Chem. Int. Ed. 2012, 51, 4012. <http://dx.doi.org/10.1002/anie.201107386>
  • Knobloch Tobias, Harmrolfs Kirsten, Taft Florian, Thomaszewski Binia, Sasse Florenz, Kirschning Andreas: Mutational Biosynthesis of Ansamitocin Antibiotics: A Diversity-Oriented Approach to Exploit Biosynthetic Flexibility. Chem Eur J of Chem Bio 2011, 12, 540. <http://dx.doi.org/10.1002/cbic.201000608>
  • Runguphan W., Maresh J. J., O'Connor S. E.: Silencing of tryptamine biosynthesis for production of nonnatural alkaloids in plant culture. Proceedings of the National Academy of Sciences 2009, 106, 13673. <http://dx.doi.org/10.1073/pnas.0903393106>
  • Kennedy Jonathan: Mutasynthesis, chemobiosynthesis, and back to semi-synthesis: combining synthetic chemistry and biosynthetic engineering for diversifying natural products. Nat Prod Rep 2008, 25, 25. <http://dx.doi.org/10.1039/b707678a>
  • Kirschning Andreas, Taft Florian, Knobloch Tobias: Total synthesis approaches to natural product derivatives based on the combination of chemical synthesis and metabolic engineering. Org Biomol Chem 2007, 5, 3245. <http://dx.doi.org/10.1039/b709549j>
  • Weist S., Süssmuth R. D.: Mutational biosynthesis—a tool for the generation of structural diversity in the biosynthesis of antibiotics. Appl Microbiol Biotechnol 2005, 68, 141. <http://dx.doi.org/10.1007/s00253-005-1891-8>
  • Lederer E.: Über Ursprung und Funktion einiger Methylgruppen in verzweigten Fettsäuren, in Pflanzensterinen und in Chinonen der Vitamin-K- und Ubichinongruppe. CMLS Cell Mol Life Sci 1964, 20, 473. <http://dx.doi.org/10.1007/BF02154061>