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Pure Appl. Chem., 1991, Vol. 63, No. 1, pp. 71-80

Separation, identification, and quantification of carotenoids in fruits, vegetables and human plasma by high performance liquid chromatography

F. Khachik, G. R. Beecher, M. B. Goli and W. R. Lusby

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  • García-Herrera Patricia, Sánchez-Mata María Cortes, Cámara Montaña, Tardío Javier, Olmedilla-Alonso Begoña: Carotenoid content of wild edible young shoots traditionally consumed in Spain (Asparagus acutifolius L., Humulus lupulus L., Bryonia dioica Jacq. and Tamus communis L.). J. Sci. Food Agric 2013, 93, 1692. <>
  • Sanches-Silva Ana, Albuquerque Tânia G, Finglas Paul, Ribeiro Tiago, Valente Ana, Vasilopoulou Effie, Trichopoulou Antonia, Alexieva Iordanka, Boyko Nadiya, Costea Cármen-Eugenia, Hayran Osman, Jorjadze Mariam, Kaprelyants Leonid, Karpenko Dmitry, Filippo D'Antuono L., Costa Helena S: Carotenoids, vitamins (A, B2 , C and E) and total folate of traditional foods from Black Sea Area countries. J. Sci. Food Agric. 2013, 93, 3545. <>
  • Carvalho Elisabete, Fraser Paul D., Martens Stefan: Carotenoids and tocopherols in yellow and red raspberries. Food Chemistry 2013, 139, 744. <>
  • Lai Jennifer F., Franke Adrian A.: Analysis of circulating lipid-phase micronutrients in humans by HPLC: Review and overview of new developments. Journal of Chromatography B 2013, 931, 23. <>
  • Sheriff Sheik Abdulazeez, Devaki Thiruvengadam: Lycopene stabilizes liver function during d-galactosamine/lipopolysaccharide induced hepatitis in rats. Journal of Taibah University for Science 2013, 7, 8. <>
  • La Frano Michael R., Woodhouse Leslie R., Burnett Dustin J., Burri Betty J.: Biofortified cassava increases β-carotene and vitamin A concentrations in the TAG-rich plasma layer of American women. Br J Nutr 2013, 110, 310. <>
  • Nolan J M, Meagher K, Kashani S, Beatty S: What is meso-zeaxanthin, and where does it come from?. Eye 2013, 27, 899. <>
  • Perveen Rashida, Suleria Hafiz Ansar Rasul, Anjum Faqir Muhammad, Butt Masood Sadiq, Pasha Imran, Ahmad Sarfraz: Tomato (Solanum lycopersicum) carotenoids & lycopenes chemistry; Metabolism, absorption, nutrition and allied health claims- A comprehensive review. Critical Reviews in Food Science and Nutrition 2013, 130824120001000. <>
  • Becerra-Moreno Alejandro, Alanís-Garza Pedro A., Mora-Nieves José Luis, Mora-Mora Juan Pablo, Jacobo-Velázquez Daniel A.: Kale: An excellent source of vitamin C, pro-vitamin A, lutein and glucosinolates. CyTA - Journal of Food 2013, 1. <>
  • Loskutova Ekaterina, Nolan John, Howard Alan, Beatty Stephen: Macular Pigment and Its Contribution to Vision. Nutrients 2013, 5, 1962. <>
  • Yue Ying, Liang Qing, Liao Yuan, Guo Yong, Shao Shijun: Electrooxidation behavior and electrochemistry determination method of the xanthophylls: Lutein in nonaqueous media. Journal of Electroanalytical Chemistry 2012, 682, 90. <>
  • Condurso C., Verzera A., Dima G., Tripodi G., Crinò P., Paratore A., Romano D.: Effects of different rootstocks on aroma volatile compounds and carotenoid content of melon fruits. Scientia Horticulturae 2012, 148, 9. <>
  • Kotake-Nara Eiichi: Intestinal Absorption of Carotenoid. Journal of Lipid Nutrition 2012, 21, 35. <>
  • Kim Suna, Kim Ji-Sun: Method Validation and Quantification of Lutein and Zeaxanthin from Green Leafy Vegetables using the UPLC System. Korean Journal of Food Science and Technology 2012, 44, 686. <>
  • Nagao Akihiko: Absorption and metabolism of dietary carotenoids. BioFactors 2011, 37, 83. <>
  • Khachik Frederick: Industrially viable processes for synthesis of biologically active hydroxycarotenoids commonly found in fruits and vegetables. Journal of Food Composition and Analysis 2011, 24, 826. <>
  • Kotake-Nara Eiichi, Nagao Akihiko: Absorption and Metabolism of Xanthophylls. Marine Drugs 2011, 9, 1024. <>
  • KHACHIK F., BEECHER G. R., GOLI M. B., LUSBY W. R.: ChemInform Abstract: Separation, Identification, and Quantification of Carotenoids in Fruits, Vegetables, and Human Plasma by High Performance Liquid Chromatography. ChemInform 2010, 22, no. <>
  • Li Binxing, Vachali Preejith, Bernstein Paul S.: Human ocular carotenoid-binding proteins. Photochem Photobiol Sci 2010, 9, 1418. <>
  • Norkus Edward P, Norkus Katherine L, Dharmarajan T.S, Schierle Joseph, Schalch Wolfgang: Serum Lutein Response Is Greater from Free Lutein Than from Esterified Lutein during 4 Weeks of Supplementation in Healthy Adults. Journal of the American College of Nutrition 2010, 29, 575. <>
  • Leveziel N., Delcourt C., Zerbib J., Dollfus H., Kaplan J., Benlian P., Coscas G., Souied E.H., Soubrane G.: Épidémiologie de la dégénérescence maculaire liée à l’âge. J Fr Ophtalmol 2009, 32, 440. <>
  • Loane Edward, Nolan John M., O'Donovan Orla, Bhosale Prakash, Bernstein Paul S., Beatty Stephen: Transport and Retinal Capture of Lutein and Zeaxanthin with Reference to Age-related Macular Degeneration. surv ophthalmol 2008, 53, 68. <>
  • Sajilata M.G., Singhal R.S., Kamat M.Y.: The Carotenoid Pigment Zeaxanthin—A Review. Comp Rev Food Sci Food Safety 2008, 7, 29. <>
  • Karlina Marina V., Pozharitskaya Olga N., Shikov Alexander N., Kosman Vera M., Makarova Marina N., Makarov Valery G.: LC Method for Quantification of Lutein in Rat Plasma: Validation, and Application to a Pharmacokinetic Study. Chroma 2008, 68, 949. <>
  • Adalid Ana Maria, Herrero-Martínez José Manuel, Roselló Salvador, Maquieira Angel, Nuez Fernando: Fast determination of prominent carotenoids in tomato fruits by CEC using methacrylate ester-based monolithic columns. Eletrophoresis 2007, 28, 4120. <>
  • Perera Conrad O., Yen Gan Mei: Functional Properties of Carotenoids in Human Health. Int J Food Prop 2007, 10, 201. <>
  • Cortés C., Esteve M.J., Rodrigo D., Torregrosa F., Frígola A.: Changes of colour and carotenoids contents during high intensity pulsed electric field treatment in orange juices. Food Toxicology 2006, 44, 1932. <>
  • Zhang J., Mori A., Chen Q., Zhao B.: Fermented papaya preparation attenuates β-amyloid precursor protein: β-amyloid–mediated copper neurotoxicity in β-amyloid precursor protein and β-amyloid precursor protein Swedish mutation overexpressing SH-SY5Y cells. Neuroscience 2006, 143, 63. <>
  • German J. Bruce, Dillard Cora J.: Composition, Structure and Absorption of Milk Lipids: A Source of Energy, Fat-Soluble Nutrients and Bioactive Molecules. Crit Rev Food Sci Nutrit 2006, 46, 57. <>
  • Bicanic Dane, Fogliano Vincenzo, Luterotti Svjetlana, Swarts Jan, Piani Giovanni, Graziani Giulia: Quantification of lycopene in tomato products: comparing the performances of a newly proposed direct photothermal method and high-performance liquid chromatography. J Sci Food Agric 2005, 85, 1149. <>
  • Schweiggert Ute, Kammerer Dietmar R., Carle Reinhold, Schieber Andreas: Characterization of carotenoids and carotenoid esters in red pepper pods (Capsicum annuum L.) by high-performance liquid chromatography/atmospheric pressure chemical ionization mass spectrometry. Rapid Commun Mass Spectrom 2005, 19, 2617. <>
  • Humphries Julia M., Graham Robin D., Mares Daryl J.: Application of reflectance colour measurement to the estimation of carotene and lutein content in wheat and triticale. J Cereal Chem 2004, 40, 151. <>
  • Ribaya-Mercado Judy D., Blumberg Jeffrey B.: Lutein and Zeaxanthin and Their Potential Roles in Disease Prevention. Journal of the American College of Nutrition 2004, 23, 567S. <>
  • ARITA Shin, OTSUKI Kojiro, OSAKI Ken-ichi, MURATA Yoshiyuki, SHIMOISHI Yasuaki, TADA Mikiro: Reduction in Photostability by the Esterification of β-Cryptoxanthin. Biosci Biotechnol Biochem 2004, 68, 451. <>
  • Bartlett Hannah, Eperjesi Frank: Age-related macular degeneration and nutritional supplementation: a review of randomised controlled trials. Ophthalmic Physiol Opt 2003, 23, 383. <>
  • Su Qing, Rowley Kevin G, Balazs Nicholas D.H: Carotenoids: separation methods applicable to biological samples. J Chromatogr B 2002, 781, 393. <>
  • Bernstein Paul S., Khachik Frederick, Carvalho Lorena S., Muir Garth J., Zhao Da-You, Katz Nikita B.: Identification and Quantitation of Carotenoids and their Metabolites in the Tissues of the Human Eye. expl eye res 2001, 72, 215. <>
  • van den Berg H, Faulks R, Granado H Fernando, Hirschberg J, Olmedilla B, Sandmann G, Southon S, Stahl W: The potential for the improvement of carotenoid levels in foods and the likely systemic effects. J Sci Food Agric 2000, 80, 880. <<880::AID-JSFA646>3.0.CO;2-1>
  • Beatty Stephen, Koh Hui-Hiang, Phil M, Henson David, Boulton Michael: The Role of Oxidative Stress in the Pathogenesis of Age-Related Macular Degeneration. surv ophthalmol 2000, 45, 115. <>
  • de Jager A.D, Ellis H, Hundt H.K.L, Swart K.J, Hundt A.F, Cheng Yung-Fong, Neue Uwe D, Woods Laura L, Su Qing, Rowley Kevin G, O���Dea Kerin: High-performance liquid chromatographic determination with amperometric detection of piroxicam in human plasma and tissues. Journal of Chromatography B: Biomedical Sciences and Applications 1999, 729, 183. <>
  • Luterotti Svjetlana, Franko Mladen, Bicanic Dane: Ultrasensitive determination of β-carotene in fish oil-based supplementary drugs by HPLC-TLS. J  Pharm Biomed Anal 1999, 21, 901. <>
  • ZHOU LEI, LEUNG IVAN, TSO MARK O.M., LAM KWOK-WAI: The Identification of Dipalmityl Zeaxanthin as the Major Carotenoid in Gou Qi Zi by High Pressure Liquid Chromatography and Mass Spectrometry. J Ocul Pharmacol Ther 1999, 15, 557. <>
  • Rock Cheryl L.: Carotenoids: Biology and treatment. Pharmacol Ther 1997, 75, 185. <>
  • Skrede G., Nilsson A., Baardseth P., Rosenfeld H.J., Enersen G., Slinde E.: Evaluation of carrot varieties for production of deep fried carrot chips—III. Carotenoids. Food Res Int 1997, 30, 73. <>
  • Granado Fernando, Olmedilla Begoña, Blanco Inmaculada, Gil‐Martinez Enrique, Rojas‐Hidalgo Enrique, Erdman John W.: Variability in the intercomparison of food carotenoid content data: A user's point of view. Critical Reviews in Food Science and Nutrition 1997, 37, 621. <>
  • NALDI L., PARAZZINI F., PELI L., CHATENOUD L., CAINELLI T.: Dietary factors and the risk of psoriasis. Results of an Italian case–control study. Br J Dermatol 1996, 134, 101. <>
  • Khachik Frederick, Beecher Gary R., Smith J. Cecil: Lutein, lycopene, and their oxidative metabolites in chemoprevention of cancer. J Cell Biochem 1995, 59, 236. <>
  • Khachik Frederick, Beecher Gary R., Li Betty W., Englert Gerhard: Synthesis of 13C-labelled (all-E,3R,3′R)-β,β-carotene-3,3′-diol (zeaxanthin) at C(12), C(13), C(12′), and C(13′) via all-E-2,7-dimethylocta-2,4,6-triene-1,8-dial-13C4. J Lab Compds Radiopharm 1995, 36, 1157. <>
  • Khachik Frederick, Englert Gerhard, Beecher Gary R., Cecil Smith J.: Isolation, structural elucidation, and partial synthesis of lutein dehydration products in extracts from human plasma. Journal of Chromatography B: Biomedical Sciences and Applications 1995, 670, 219. <>
  • Yakushina L., Taranova A.: Rapid HPLC simultaneous determination of fat-soluble vitamins, including carotenoids, in human serum. J  Pharm Biomed Anal 1995, 13, 715. <>
  • Clinical development plan: β-Carotene and other carotenoids. J Cell Biochem 1994, 56, 110. <>
  • Biacs Peter A, Daood Hussein G.: High-performance Liquid Chromatography with Photodiode-array Detection of Carotenoids and Carotinoid Esters in Fruits and Vegetables. J  Plant Physiol 1994, 143, 520. <>
  • Astorg P., Gradelet S., Leclerc J., Canivenc M.-C., Siess M.-H.: Effects of β-Carotene and canthaxanthin on liver xenobiotic-metabolizing enzymes in the rat. Food Toxicology 1994, 32, 735. <>
  • Mangels Ann Reed, Holden Joanne M, Beecher Gary R, Forman Michele R, Lanza Elaine: Carotenoid content of fruits and vegetables: An evaluation of analytic data. Journal of American Diet Association 1993, 93, 284. <>
  • Chug-Ahuja Jaspreet K, Holden Joanne M, Forman Michele R, Mangels Ann Reed, Beecher Gary R, Lanza Elaine: The development and application of a carotenoid database for fruits, vegetables, and selected multicomponent foods. Journal of American Diet Association 1993, 93, 318. <>
  • Barua Arun B., Furr Harold C., Janick-Buckner Diane, Olson James A.: Simultaneous analysis of individual carotenoids, retinol, retinyl esters, and tocopherols in serum by isocratic non-aqueous reversed-phase HPLC. Food Chem 1993, 46, 419. <>
  • Parry Andrew D., Horgan Roger: Abscisic acid biosynthesis in roots. Plant 1992, 187, 185. <>
  • Khachik Frederick, Englert Gerhard, Daitch Charles E., Beecher Gary R., Tonucci Linda H., Lusby William R.: Isolation and structural elucidation of the geometrical isomers of lutein and zeaxanthin in extracts from human plasma. Journal of Chromatography B: Biomedical Sciences and Applications 1992, 582, 153. <>
  • BEECHER G. R., KHACHIK F.: Qualitative Relationship of Dietary and Plasma Carotenoids in Human Beings. Ann N Y Acad Sci 1992, 669, 320. <>
  • Cooney R.V., Bertram J.S., Hankin J.H., Kolonel L.N., Miyake A., Billings K., Bourne W.: Relationship between dietary, serum, and tissue levels of carotenoids. cancer lett 1991, 61, 81. <>