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Pure Appl. Chem., 2013, Vol. 85, No. 8, pp. 1725-1758

Published online 2013-07-29


Glossary of terms used in medicinal chemistry. Part II (IUPAC Recommendations 2013)

Derek R. Buckle1*, Paul W. Erhardt2, C. Robin Ganellin3, Toshi Kobayashi4, Thomas J. Perun5, John Proudfoot6 and Joerg Senn-Bilfinger7

1 DRB Associates, 18 Hillfield Road, Redhill, Surrey, RH1 4AP, UK
2 University of Toledo, College of Pharmacy, Center for Drug Design and Development, 2801 West Bancroft Street, Toledo, OH 43606-3390, USA
3 Department of Chemistry, Christopher Ingold Laboratory, University College London, 20 Gordon Street, London, WC1H 0AJ, UK
4 PhRMA, 4th Floor, Landic II Toranomon Building, 3-7-8 Minato-ku, 105-000 Japan
5 47731 Old Houston Highway, Hempstead, TX 77445, USA
6 Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, P.O. Box 368, Ridgefield, CT 06877, USA
7 Altana Pharma AG, Byk-Gulden Str. 2, D-78467 Konstanz, Germany

Abstract: The evolution that has taken place in medicinal chemistry practice as a result of major advances in genomics and molecular biology arising from the Human Genome Project has carried with it an extensive additional working vocabulary that has become both integrated and essential terminology for the medicinal chemist. Some of this augmented terminology has been adopted from the many related and interlocked scientific disciplines with which the modern medicinal chemist must be conversant, but many other terms have been introduced to define new concepts and ideas as they have arisen. In this supplementary Glossary, we have attempted to collate and define many of the additional terms that are now considered to be essential components of the medicinal chemist’s expanded repertoire.